A recent publication from the group of Prof. Kuivenhoven, from the Department of Pediatrics, Section Molecular Genetics, University Medical Center Groningen.
BiomarkerBay collaborates intensively with biobanks and patient cohorts. One of them is Lifelines, a general population biobank with 167,000 residents of the Northern Netherlands that will be monitored over a period of 30 years, from children via parents through grandparents (read more here). The added value of having access to such a collection of data and sample was presented in a recent publication by Balder et al. where Lifelines data from 8071 children (8-18 years old) were used to generate reference lipid values.
In the total cohort the researchers noted marked dynamic changes in lipid and lipoprotein levels over age, which were in part gender specific. The data highlight a high and unexpected prevalence of severely elevated LDL-c (>190 mg/dL) in both boys and girls. The contemporary reference ranges for plasma lipids obtained via the Lifelines cohort could be important for physicians to identify children at increased risk of premature atherosclerosis, especially familial hypercholesterolemia.
More information at :"Pediatric lipid reference values in the general population: The Dutch lifelines cohort study." (Balder JW et al., J Clin Lipidol. 2018 May 26). See publication.