Determination of reference intervals for urinary steroid profiling using a newly validated GC-MS/MS method

A new publication from Prof. Ido Kema, Laboratory Medicine, in collaboration with the Endocrinology department of the UMCG, has been released.

Urinary steroid profiling (USP) is a powerful diagnostic tool to asses disorders of steroidogenesis. The publication introduces a new GC-MS/MS method for USP which is applicable for high throughput analysis. Widely applicable age and sex specific reference intervals have been defined for 33 metabolites and their diagnostic ratios and also for use of oral contraceptive pills. The method was used to follow androgen metabolite excretion in two hundred and forty healthy subjects aged 20-79 years, stratified into six consecutive decade groups each containing 20 males and 20 females, were included. In addition, 40 women aged 20-39 years using oral contraceptive pills were selected. 

The assays, which are validated for patient care, are available on the BiomarkerBay database.

Results and full publication are available in: "Determination of reference intervals for urinary steroid profiling using a newly validated GC-MS/MS method (Jong et al, Clin Chem Lab Med, 2017). The link is here. 

---

• To get more information about the assay and request a quote, contact us.